In 2021, there are many drugs in the US market that will lose patent exclusivity. Here we list top 10 of them. These drugs may be grabbed market share by cheaper generics, which provides opportunities for generic drug manufacturers. The top 10 drugs are Lucentis (Genentech/Roche), Bystolic (AbbVie/Allergan), Vascepa (Amarin), Nothera (Lundbeck), Narcan (Emergent Biosolutions), Brovana (Sunovion), Sutent (Pfizer), Saphris (AbbVie/Allergan), Amitiza (Mallinckrodt), and Feraheme (Amag Pharma).
Lucentis (Genentech/Roche)
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Generic Name: Ranibizumab
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CAS NO.: 347396-82-1
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U.S. sales in 2020: $1.61 billion
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Theraputic Area: age-related wet macular degeneration, macular edema after retinal vein occlusion, diabetic macular edema and diabetic retinopathy
Bystolic (AbbVie/Allergan),
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Generic Name: Rebivolol
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Molecular Formula: C22H25F2NO4
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Molecular Weight: 405.43
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CAS Registry Number: 118457-14-0
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U.S. sales in 2020: undisclosed (2019 sales of $600 million)
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Theraputic Area: Hypertension
Vascepa (Amarin)
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Generic Name: Eicosapentaenoic acid ethyl ester
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Molecular Formula:C22H34O2
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Molecular Weight: 330.50
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CAS Registry Number: 73310-10-8
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U.S. sales in 2020: $598 million
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Theraputic Area: hypertriglyceridemia and cardiovascular disease
Nothera (Lundbeck)
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Generic Name:Droxidopa
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Molecular Formula:C9H11NO5
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Molecular Weight:213.19
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CAS Registry Number:23651-95-8
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U.S. sales in 2020: $416 million
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Theraputic Area:Neurogenic orthostatic hypotension
Narcan (Emergent Biosolutions)
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Generic Name:Naloxone
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Molecular Formula:C19H21NO4
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Molecular Weight: 327.37
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CAS Registry Number: 465-65-6
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U.S. sales in 2020: $311 millio
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Theraputic Area:Opioid overdose
Brovana (Sunovion)
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Generic Name:arformoterol
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Molecular Formula:C19H24N2O4
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Molecular Weight:344.41
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CAS Registry Number:67346-49-0
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U.S. sales in 2020: approximately $275 million
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Theraputic Area:chronic obstructive pulmonary disease
Sutent (Pfizer)
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Generic Name:sunitinib
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Molecular Formula:C22H27FN4O2
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Molecular Weight:398.47
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CAS Registry Number:557795-19-4
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U.S. sales in 2020: $2.23 million
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Theraputic Area:gastrointestinal stromal tumors, advanced renal cell carcinoma and pancreatic neuroendocrine tumors
Saphris (AbbVie/Allergan)
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Generic Name:asenapine
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Molecular Formula:C17H16ClNO
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Molecular Weight:285.77
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CAS Registry Number:65576-45-6
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U.S. sales in 2020: undisclosed (IQVIA estimates the market size to be 217 million US dollars)
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Theraputic Area:schizophrenia and type I bipolar disorder
Amitiza (Mallinckrodt)
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Generic Name:Asenapine
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Molecular Formula:C17H16ClNO
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Molecular Weight:285.77
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CAS Registry Number:65576-45-6
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U.S. sales in 2020: $180 million
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Theraputic Area:constipation and irritable bowel syndrome
Feraheme (Amag Pharma)
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Generic Name:ferumoxytol
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CAS Registry Number:722492-56-0
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U.S. sales in 2020: $150 million
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Theraputic Area:Iron deficiency anemia
